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The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a heterodimer with the retinoid X receptor (RXR). Calcitriol signalling regulates a variety of biological effects, including calcium as well as metabolism of phosphorous, parathormone release cell proliferation, and the control of innate and adaptive immunity.

A T > C alteration in the promoter region of the VDR variant (rs11568820) removes the binding Cdx2’s transcription factor binding site just upstream of exon 1. This leads to a smaller protein with decreased transcriptional activity. The F allele of this variant is located at a high rate in Asians and Europeans and at a low frequency in Sub-Saharan Africa.

The results of this study improve our understanding of how VDR gene polymorphisms affect the response to dietary supplements with calcium calcitriol. The carriers of the Visit This Link TaqI polymorphism and the FF genotype of the FokI polymorphism have higher transcriptional activation of VDR and are associated with improved calcium absorption and bone mineral density as well as reduced risk of fractures [34 35, 34]. To gain a better understanding of the role these genetic variants play in vitamin D supplementation we need to study more using an identical design.